Question

Sometimes I-Cell disease is considered a type of mucopolysaccharidosis. What are the differences and similarities between I-Cell disease and other mucopolysaccharidoses such as Hunter’s or Hurler’s syndrome?

Answer 1

Ans- the similarities include that these both are lysosome related disease and there symptoms are also similar. The enlargement of various organs occur in both diseases.

The main difference between them is that in I cell disease the lysosome is not targeted due to which the protein are directly excreted from cells and a regular pathway is not followed while in hurler disease the enzyme present in the lysosomes show some dysfunction or some times they become non functional.