Question

Choose a cell structure or a step in the flow of genetic information to design an antibacterial or antifungal drug. Explain how the drug will have specificity against the microbe you have chosen and what function will be inhibited.

Answer 1

In the above given question we can find out Antimicrobial drug using various specific methods like both Whole cell screening and also gene flow methods specific for function to get inhibited.

In whole cell screening mainly screen allows selection investment into the chemical structure of bacteria like mainly compound which are easily available and we observe its penetration into bacterial cells and provides opportunity to discover various compounds that inhibits the growth that engage multiple targets

In my point mainly Focus on gene flow to produce antibacterial or antibiotic that target on RNA mainly. RNA has diverse structure that includes bulges and internal loops and knowing marked difference between us prokaryotic and eukaryotic rRNA has led to use of development of novel drug to inhibit translation mainly in cell.it targets for small molecules for bacterial ribosomes comprised with30s and 50s ribonucleoprotein subunit contains antibiotic binding sites by using X ray crystallography studies to get information on ribosomal subunits. And also many techniques made used to discovery that targets RNA like High resolution NMR, Surface plasmoic resonance and there is a new technique developed called Scintillation proximity assay (SPA) is a means of screening inhibitors of RNA- protein interaction by this we uses labelled complementary oligonucleotides to monitor the change in the equilibrium between folded and unfolded state of RNA stem loop structure binding by small molecules and disrupt bacterial ribosomes mainly.