Question

Question 5
Which of the following is the best example of cross-reactivity?

Increased likelihood of estradiol binding to ERa over ERb
Structurally different receptor types for thyroid hormone on liver and muscle tissue
The binding of estrogen to androgen receptors
All of the above

Answer 1

Cross-reactivity occurs when a ligand binds to a structurally different receptor. Although the speicificity between a ligand and its receptor is highly specific, minute structural differences in the makeup of the receptor can make the ligand bind non-specifically.

An example of cross-reactivity is the structurally different receptor types for thyroid hormone on liver and muscle tissue can cause thyroid hormone to bind to either of them. So, option (b) is correct.