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Name one distinguishing feature of TI-1 and TI-2 antigens.  

  1. Name one distinguishing feature of TI-1 and TI-2 antigens.  
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Answer #1

T independent antigen(TI) elicits antibody production by B and T lymphocyte involvement. The 2 subgroups of TI are TI-1 and TI-2 antigen,and they are different in mechanism of activating B lymphocytes. TI-1 antigen have an intrinsic B cell activating activity ie, they can directly cause proliferation and differentiation of B lymphocytes which is without T cell stimulation and independently of their BCR specificity.

While TI-2 antigens activates B lymphocytes ,by cross linking of a critical number of B cell receptors which leads to accumulation of BCRs and cross activation of these receptors. This results in proliferation and differentiation of B lymphocytes and production of antibodies. TI-2 can only activate mature B lymphocytes.

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