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10. What ECM peptide is mimicked on the surface of tissue culture plastics to aid cellular...

10. What ECM peptide is mimicked on the surface of tissue culture plastics to aid cellular attachment?

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Answer #1

Weak cell-surface adhesion of cell lines to tissue culture surfaces is a common problem and present technical limitations for experiment design. Several surface coating protocols have been developed to overcome this problem.

ECM (extra cellular metrix) play an important role in proliferation, cell migration, growth and development. Collagen I, Collagen IV, Fibronectin and Laminin ECM (extra cellular metrix) protein from which peptide motief derived are used for cell surface coating. Such molecules can mimic entire surfaces filled with the crossponding molecules.  

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