Question

Chloramphenicol is an antibiotic used to treat several bacterial infections. However it causes severe side effects like bone marrow suppression.

Some mice show resistance to this antibiotic side effect. The following is a study done in mice in which researchers tried to determine the mode of inheritance of this trait. Read an extract of their results and conclude which effect is happening:

The isolation and characterization of CAP-resistant cells re-
sulting from the fusion between enucleated (without nucleus) CAP-resistant mouse cells and nucleated, CAP-sensitive (not resistant) mouse cells has been described. These fusion products, or cybrids, appear at high frequency and are stable with respect to CAP resistance. They
resemble the nucleated parent cell in terms of chromosome
complement and nuclear markers and the enucleated parent
cell in terms of CAP resistance. [...]Furthermore, control fusions be-
tween enucleated and nucleated CAP-sensitive cells produce
no CAP-resistant cells. Fusions between nucleated, CAP-
resistant and CAP-sensitive cells under the same selective
conditions produced CAP-resistant hybrids at a frequency
100 times lower than the rate of appearance of CAP-resistant
cybrid.

a.Maternal effects

b. Cytoplasmic inheritance

c.Environmental effects

d. Epigenetic effects

Answer 1

• Here the cytoplasm has some material which is responsible for providing the resistance against chloramphenicol in CAP resistant mouse.
• So that the answer is "Cytoplasmic inheritance".

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