Question

1. For protein secondary structure, which of the following is incorrect?

A. Secondary structure consists of α-helices and β-pleated sheets

B. The interactions between C=O and N-H groups are hydrogen bonding interactions

C. Secondary structure is created by bonding between C=O and N-H groups in the peptide backbone

D. A protein can have either α-helices of β-pleated sheets, but never both

2. With regard to protein folding and denaturation, which one is incorrect?

		When egg white solidifies during heating, this is an example of protein denaturation
		Molecular chaperones are proteins that help other proteins fold correctly
		When a protein denatures, the covalent bonds linking amino acids together to form primary structure are broken
		Spongiform encephalopathies are examples of diseases caused by protein mis-folding

Answer 1

Answer 1) D is the answer.

Explanation:

Secondary structure of protein is categorised into alpha helix and beta sheets. The hydrogen bond is found between C=O and NH2 group. This hydrogen bonding is responsible for making the secondary alpha helix. The protein can have both aloha helix and beta sheets.

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Answer 2) C is the answer.

Explanation:

The hydrogen bind is break down in the protein. This leads to denaturation of the enzyme. The molevular chaperone folds the proteins correctly. The peptide bond is not break down into the protein during the denaturation. Spongiform encephalitis is responsible for protwin misfolding.