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Aspirin is an inhibitor of the enzyme prostaglandin synthase. How dies aspirin reduce the inflammatory pain...

Aspirin is an inhibitor of the enzyme prostaglandin synthase. How dies
aspirin reduce the inflammatory pain and cause blood “thinning”?

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Answer #1

Aspirin is an irreversible inhibitor of the cyclooxygenase (COX) enzyme which is involved in the production of inflammatory substances such as prostaglandins.
Aspirin also interferes with blood clotting. One of the downstream molecules in blood clotting is Thromboxane A2 formed by prostaglandins. Thromboxane A2 usually stimulates the activation of new platelets and increases their aggregation. Inhibition of cyclooxygenase results in decreased synthesis of thromboxane A2 and coagulation of blood is reduced.

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