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gene regulatory protein that functions as a brake and suppresses the cell cycle in G1 in...

gene regulatory protein that functions as a brake and suppresses the cell cycle in G1 in mammalian cells is a. the retinoblastoma protein b. the cdc25 phosphatase c. eIF4E d. ubiquitin ligase e. none of the above

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Answer #1

Answer: A retinoblastoma protein.

Retinoblastoma protein restricts cells by entering into S phase. So cell progression from G1 to S phase of cell cycle is stopped, RB binds and inhibits E2F-DP E2 promoter-binding–protein-dimerization partner dimers, which are transcription factors of E2F family which pushes cells to S phase. By keeping E2F-DP inactivated RB maintains cell in the G1 phase, and acting as growth suppressor

cdc25 phosphatase which are there to inactivate CDKs when there is any DNA damage found.

eIF4E Eukaryotic translation initiation factor 4E which doesnt play any role in cellc cycle suppression

ubiquitin ligase is the player in ubiquitin proteasome system.

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