Question

Which of the following statements is correct about immunological tolerance?

Multiple Choice

A.) T-cell tolerance induced in the thymus and B-cell tolerance induced in the bone marrow is called central tolerance.

B.) Central tolerance is needed to prevent immune reactions against self antigens because many antigens are tissue-specific and are not present in the thymus or bone marrow.

C.) Central tolerance is thought to be based largely on incomplete activation signals given to the lymphocyte when it encounters self antigens in the periphery of the body.

D.) T-cell tolerance induced in the thymus and B-cell tolerance induced in the bone marrow is called peripheral tolerance.

Answer 1

Answer. (A) T-cell tolerance induced in the thymus and B-cell tolerance induced in the bone marrow is called central tolerance.

Immunological tolerance is the process by which the immune system does not attack an antigen (self or foreign). Tolerance to self antigen is called self tolerance (antigen-specific unresponsiveness to foreign antigen is known as acquired immunological tolerance). It occurs during both T and B lymphocytes development.

Central tolerance is the removal or inactivation of self reactive B and T cells during their development in the bone marrow and thymus, respectively.

Peripheral tolerance is induced by self antigens encountered in the peripheral lymphoid organs.