Question

H+ from Lactic Acid and Carbonic Acid bind to _______ amino acids in beta globin, thus increasing Hemoglobion's shift to the ______ state.

Answer 1

Hydrogen ions from lactic acid and carbonic acid bind to the histidine amino acids in beta globulin, thus increasing hemoglobin s shift to T or tensed state-deoxyform

A decrease in pH has effects on the haemoglobin conformation which effects the reversible shift of haemoglobin s affinity for Oxygen. When pH decreases- (increase in H+) , ionic bonds are formed in the amino acids which increases the release of oxygen to the tissues. It is conformation which has less affinity for oxygen

The R state is reverse to this. It is the state where the oxygen affinity is more. The R and T state are in equilibrium and allosteric to each other.