Question

A seventy year-old male patient presented with complaints of weakness and involuntary movements in his left...

  1. A seventy year-old male patient presented with complaints of weakness and involuntary movements in his left arm, changes in behavior, and forgetfulness. He also developed mutism after nearly three months. Although no microbes were recovered from his cerebral spinal fluid, high levels of Protein 14-3-3 were found in this fluid. Following his death, examination of his brain showed extensive degeneration such that his brain resembled a sponge.
  1. What disease is it likely that this man has?

  1. What is the causative agent involved in this disease?
  1. How does this infectious entity cause the neurodegeneration?

Homework Answers

Answer #1

a) High levels of Protein 14-3-3 are a diagnosis for the Creutzfeldt-Jakob disease (CJD). The man was most likely affected by this disease.

b) The disease is caused by an abnormal form of a cellular glycoprotein. The abnormal form is calles as a prion.Prions are misfolded or abnormally folded proteins with the ability to spread the misfolded shape to the nomral proteins.

c) The prions destroy neurons by destroying the signal transmission between neurons. They affect the dendritic spines, which receive signal from other neurons, thus eventually leading to neurodegeneration.

Know the answer?
Your Answer:

Post as a guest

Your Name:

What's your source?

Earn Coins

Coins can be redeemed for fabulous gifts.

Not the answer you're looking for?
Ask your own homework help question
Similar Questions
A 25-year-old male sportsman visited his physician with complaints of sudden muscle weakness, headache, dizziness during...
A 25-year-old male sportsman visited his physician with complaints of sudden muscle weakness, headache, dizziness during physical exercise, increased frequency and volume of urination. These symptoms appeared 3 weeks ago. On examination: blood cell count is within the normal range, there is evidence of hypernatremia and hypokalemia; blood pressure is 165/110 mm Hg; daily urine volume is 3500 ml, hyposthenuria; an X-ray examination of the chest shows increased heart size. What forms of pathology may be suspected in this patient?...
A 52-year-old male presented to the emergency department complaining of muscle pain and weakness for the...
A 52-year-old male presented to the emergency department complaining of muscle pain and weakness for the last two day. He also noticed that his urine is becoming dark (red to brown). The patient has no history of accidents or trauma and no symptoms of anemia. The patient is known to have history of hypertension, Type II diabetes, hypercholesterolemia, and ischemic heart disease. 5-weeks before he came to the emergency he had suffered a myocardial infarction. He was treated in the...
medical terminology) case study for patient case find all medical terms and defined them. Introduction: The...
medical terminology) case study for patient case find all medical terms and defined them. Introduction: The patient Mr. J, a 58 years old African-American, admitted in the Emergency Department with complaints of loss of balance followed by the altered level of consciousness (ALOC), left-sided hemiparesis, dysarthria, and facial droop. He denied chest pain, visual disturbances, cephalalgia, trauma, bowel incontinence, urinary incontinence, etc. He had stable vital signs except blood pressure of 150/90 mm of Hg, indicating hypertension. After necessary diagnostic...