a) High levels of Protein 14-3-3 are a diagnosis for the Creutzfeldt-Jakob disease (CJD). The man was most likely affected by this disease.
b) The disease is caused by an abnormal form of a cellular glycoprotein. The abnormal form is calles as a prion.Prions are misfolded or abnormally folded proteins with the ability to spread the misfolded shape to the nomral proteins.
c) The prions destroy neurons by destroying the signal transmission between neurons. They affect the dendritic spines, which receive signal from other neurons, thus eventually leading to neurodegeneration.
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