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ATP is the most frequently used source of energy in the cell, but some processes, like...

ATP is the most frequently used source of energy in the cell, but some processes, like microtubule polymerization, favor GTP. why might GTP sometimes be a better option in these cases?
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Answer #1

Ans .Microtubules are polymers of tubulin that form part of the cytoskeleton and provide structure and shape to eukaryotic cells.

Microtubules assemble only in the presence of GTP- bound tubulin heterodimers , but the   - tubulin-bound GTP is rapidly hydrolyzed to GDP after assembly.

The role of GTP in microtubule assembly is to give tubulin a conformation favourable for polymerization, and then to shift equilibrium irreversibly toward polymerization through the hydrolysis of tubulin - bound GTP. The hydrolysis of GTP is necessary for subsequent disassembly of microtubules.

It is apparent that in order for ATP to support assembly , the E-site must contain GTP which then becomes hydrolyzed.Therefore , ATP cannot be interacting with tubulin at this site.

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