Question

1. Match the following kinase with their appropriate function(s). The answer choices can be used once, more than once or not at all.

activates APC---> Choose: M cdk, G1/S cdk, S cdk

activates S cdk--> Choose: M cdk, G1/S cdk, S cdk

activates condensin--> Choose: M cdk, G1/S cdk, S cdk

2. What is the function of Kinesin 13?

A. triggers catastrophes in microtubules

B. elongate the cell

C. move chromosomes to the metaphase plate

D. attached microtubules to the kinetochore

Answer 1

1) APC is activated in M cdk because it requires cdc20 protein for its activation which bind to APC and activates it at mitosis. S cdk is activated at G1/S cdk or late G1 as it is required for initiation of replication after binding to a protein kinase and phosphorylating ORC complex. Condension is activated during M cdk as cyclin A cdk 1 phosphorylation causes activation of condensin in the centromere chromatids. 2) option A is correct. They are involved in controlling microtubule dynamics. Also causing depolymerisation of microtubules at both the ends.