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T or F 1. lower pH and CO2 binding promote the release of O2 in the...

T or F
1. lower pH and CO2 binding promote the release of O2 in the tissues
2. higher pH helps the binding of oxygen to hemoglobin
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Answer #1

Answer 1. True

Factors such as decrease in pH (increase in acidity), increase in temperature, and increase in pCO​​​​2 result in decreased affinity of haemoglobin towards Oxygen, and thus favouring dissociation of Oxygen. This a causes a shift towards the right in the Oxygen- Dissociation curve.

Answer 2. True

Higher pH (decrease in [H+]) causes a left-shift in the Oxygen-Dissociation curve, meaning an increase in the affinity of haemoglobin towards Oxygen. This is because of Bohr's effect, which states that haemoglobin's oxygen-binding affinity is inversely proportional to the pH.

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