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How does nonhomologous end joining repair a double-strand break in DNA?

How does nonhomologous end joining repair a double-strand break in DNA?

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The double stranded breaks on the DNA because of any regions can be either repaired with non-homologous end joining or homologous end joining. In non-homologous end joining, double stranded break is recognised by heterdimer of Ku70 and Ku80. This heterodimer tries to pull both ends of double strand break towards each other, followed by recruitment of DNA ligase which ligates two strands with each other.

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This methods generated Indels which can be lethal to the cell.

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