The enzyme alcohol dehydrogenase can oxidize ethanol or methanol (both can be substrates). What oxidation product of methanol would be expected to be present in these poisoned individuals, and what is a potential treatment based upon your knowledge of enzymes?
ethanol = CH3CH2OH
methanol = CH3OH
formaldehyde = CH2O
methane = CH4
Group of answer choices
Formaldehyde; administer methanol to saturate the alcohol dehydrogenase enzyme
Methane; administer methanol to saturate the alcohol dehydrogenase enzyme
Formaldehyde; administer ethanol to compete with the methanol at the active site
Methane; administer ethanol to compete with the methanol at the active site
1. Answer: Option C is correct
Explanation:
Alcoholo dehydrogenase catalyzes the following reactions.
Ethanol <------> Acetaldehyde
Methanol <------> Formaldehyde
Methanol and formaldehyde are poisonous to humans.
Formaldehyde is far dangerous than methanol.
So, ethanol must be administered to methanol poisoned individuals.
As a result, the alcohol dehydrogenase enzyme is saturated with
ethanol and hence it cannot use methanol as a substrate.
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