Question

which of the following is(are) true of oxygen toxicity?

1) free radicals are produced in an abundance, leading to cell damage and death

2) can result in physiologic shunting

3) can be avoided by limiting 02 exposure to 70% concentration at all times

4)is marked by an increase in neutrophils and macrophages, common immune response

1,2,3

1,2,4

2,3,4

1,2,3,4

Answer 1

The correct answer is option 2, which is 1,2,4.

Reason:- In case of oxygen toxicity, free radicals are formed in abundance, which causes cell damage and death. The major damage occurs in the pulmonary area which reduces the surfactant and causes alveolar damage. As the surfactant is reduced, there occurs a marked increase in inflammatory immune responses which can be seen by an increased activity of macrophages. Oxygen toxicity can also result in physiological shunting.