Question

What cells are at the bottom of the gut crypt, and why are they placed there?...

What cells are at the bottom of the gut crypt, and why are they placed there?

Group of answer choices

Paneth cells, they provide signals to maintain stem cells

Absorptive cells, they aid in digestion

Precursor cells, they make more cells

Paneth cells, they are stem cells

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Answer #1

Peneth cells are placed at the bottom of gut crypt. They provide host defence against microbes in small intestine.The principal defense molecules secreted by Paneth cells are alpha-defensins, also known as cryptdins. Their location is adjacent to stem cells that they play a critical role in defending epithelial cell renewal. These cells  appear capable of responding to intestinal insults by changing into proliferative cells with stem cell-like character that assist in tissue repair.

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