Question

1.Can be activated by ischemia (dec blood supply; loss of oxygen)

A.necrosis B.apotosis C. autophagy D. internal apoptosis only

2. if transported to the lysosomes, lipids are never digested

A. true B. false

3. protein associated wiht 'late signaling' during necrosis

A. caspase 3 B. LC3 C. RIP3 D. IAF protein

4.activation of apoptosis invloves

A. activation or proteinases B. dephosphorylation of LC3/5 C. cleavage of RIP3 D. cleavage of IAF protein

Answer 1

1. ​​​​​​A). Necrosis- . Ischemic injury is caused by diminished or absent blood flow. ... Ischemia may be relative or complete, in which case it usually results in coagulative necrosis. Relative ischemia can occur as a result of low blood pressure (hypotension), marked increases in cellular metabolism, and vascular stenosis... Prerequisites are- During ischemia, anaerobic metabolism prevails, which produces a decrease in cell pH. ... Ischemia also depletes cellular ATP which inactivates ATPases (e.g., Na+/K+ ATPase), reduces active Ca2+ efflux, and limits the reuptake of calcium by the endoplasmic reticulum (ER), thereby producing calcium overload in the cell....
2. False- Lysosomes contain about 50 different degradative enzymes that can hydrolyze proteins, DNA, RNA, polysaccharides, and lipids.

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