Question

18. Which of the following is involved in the regulation or execution of apoptosis (pick the last option if they are all involved). (a) Bcl2 (b) p53 (c) Mitochondria (d) Caspases (e) They are all involved in apoptosis

Answer 1

Bcl-2 family of Proteins is involved in regulation of apoptosis. They can either inhibit or induce apoptosis.

p53 is one of the most important protein for any cell. It is called guardian of our genome as it is involved in DNA repair, Tumor suppression and apoptosis of cell if damage to the cell is irrepairable. So it can also execute apoptosis

Mitochondria also have a role in apoptosis as Bcl-2 proteins make mitochondria release several membrane proteins like Cytochrome from its membrane into the cytosol. This activates caspases and can induce apoptosis.

Caspases are the enzymes which are responsible for apoptosis. They have Cysteine protease activity. All the caspases are proteases and once induced, they start chain reactions which ultimately result in cell death.

So all the options are right.

The right option is Option (e) They all are involved in apoptosis