The function of some cyclin-dependent protein kinases (CDKs) has been remarkably conserved in evolution. Indeed, coding sequence for the human protein Cdc2 is able to substitute for the CDC28 gene in S. cerevisae and allow the yeast cell to grow and mate essentially normally. The following sequence near the NH2-end of the molecule is identical in both proteins: Gly-Glu-Gly-Thr-Tyr-Gly-Val-Val-Tyr-Lys-Ala. Does this mean that nucleotide sequences of the two genes coding for this region of the polypeptide are also identical? Explain your answer.
Does this mean that nucleotide sequences of the two genes coding for this region of the polypeptide are also identical?
No.
Two proteins may have identical polypeptide sequence, but there is a possibility that their coding mRNA and DNA sequences differ due to redundant nature of the genetic code.
Some (most of the) amino acids can be encoded by more than one codon. This makes different possibilities in DNA sequence that encodes these amino acids.
For example, leucine is encoded by UUA, UUG, CUU, CUC, CUA, & CUG.
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