Question

A female patient has been referred to you who has hemophilia A. Neither of her biological parents have any symptoms of this disorder.

a. Describe one possible hypothesis for why this patient has this disorder that includes a proposal for what the genotype of this patient is and an explanation of how she can have these symptoms.

b. Propose an experimental test or tests of this patient and/or her parents that will determine whether your hypothesis in (a) is correct.

c. Describe the results you would expect from your test if your hypothesis is correct.

PLEASE BE SPECIFIC

Answer 1

A. HAEMOPHILIA IS AN EXPRESSION OF RECESSIVE CONDITION. IT CAN BE HYPOTHESIZED THAT

PATIENT IS A FEMALE THIS SHOWS THAT IT IS NOT A X LINKED RECESSIVE ALLELE BUT IS RALATED TO OTHER 40 CHROMOSOMES AND CAN BE CONCLUDED THAT BOTH THE PARENTS ARE HETEROZYGOUS CARRIERS.   

B. AND C. IF PATIENT IS MATED WITH MALE HOMOZYGOUS FOR DOMINANT NORMAL CONDITION THEN THERE WILL BE NO PHENOTYPE OF HAEMOPHILIC IN F1 GENERATION BUT ALL WILL BE CARRIER IN FROM OF HETEROZYGOUS.

PARENTS WITH 4 CHILDREN 1 WILL NOT BE CARRIER AT ALL, 2 WILL BE CARRIER AND 1 PATEINT ALREADY OBSERVED