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The failure of monosomic individuals to survive is most closely connected with which of the following...

The failure of monosomic individuals to survive is most closely connected with which of the following terms?

a. gene duplication

b. gene redundancy

c. X-inactivation

d. inversion

e. haploinsufficiency

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Answer #1

The correct answer is option e - haploinsufficiency

Explanation: Monosomy means one chromosome of a pair of homologous chromosome is missing. Haploinsufficiency means a single copy of a gene is unable to produce the standard genotype. In monosomy, as one chromosome is missing of a homologous pair, the genes on the existing pair of chromosome becomes single copy and therefore haploid. They cannot meet the need of the body and hence the monosomic person dies.

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