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What are the roles of thrombin in coagulation

What are the roles of thrombin in coagulation

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Blood coagulation is a process which involves many clotting factors and thrombin enzymes. Prothrombin upon acivation converts into the thrombin with the help of clotting factors. Thrombin converts fibrinogen (soluble) into fibrin monomer (long,sticky threads of insoluble fibrin). The fibrin threads form a mesh like structure in which platelets, blood cells and plasma are trapped. This fibrin clot is not stable. A clotting factor XIIIa make this fibrin clot stable. This clotting factor (XIIIa) is obtained from clotting factor XIII with the help of thrombin enzyme.

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