Question

Describe the mechanisms behind Huntingtons disease and sickle cell, connecting how the genetic anomaly relates to the phenotype/observed symptoms.

Answer 1

Huntingtons disease is induced by extension of cytosine-adenine-guanine recapitulation in the gene concerning huntingtin, which gives rise to the loss of the neuron inside the striatum and cortex and to the arrival of intranuclear additions concerning the neurons mutant huntingtin. Huntingtin plays a crucial role in protein handling, vesicle movement and transcriptional management. Therefore, failure in action of an ordinary protein and harmful acquisition of action of the mutatnt concerned with huntingtin provide disruption to different intracellular pathways. Moreover, dopamine poison, metabolic deterioration, non functioning of mitochondria and autophagy coounts for dynamic decay in Huntingtons disease. Inspite of a lot of researches, no cure have been foound for this neurodegenerative disease.