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1. Briefly describe the clinical significance of channelopathies. What pathophysiological mechanisms are involved in cases of...

1. Briefly describe the clinical significance of channelopathies. What pathophysiological mechanisms are involved in cases of patients with long QT syndrome? What danger may these patients be facing during their lives?

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Answer #1

Channelopathies are the diseases that are caused by disturbed function of the ion channels.

clinically they cause the fo.lllowing-

  • Hyperkalemic periodic paralysis
  • Hypokalemic periodic paralysis
  • myotonia congenita
  • paramyotonia congenita.

The Q-T interal in the ECG represents the time it will the heart to contract and then refill with blood before next contraction.

Prolonged QT intervals means there is a long refractory period for the heart.

This may be caused due to some electrical abnormality in thr heart.

Dangers to the patient -the patient with prolonged QT interval are at a high risk of-

  • fainting, the most common
  • seizures, which results from hypoxia to the brain
  • Sudden death, which is caused due to the irregular rhyth of the heart. Howeevr the patient can be saved if defribillators are used in time.
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