Answer Each question with an explanation.
1) Which of the following protein is a lipid kinase?
a. EGFR
b. CaM Kinase
c. MLCK
d. PI3K
2)Which of the following protein is activated by calcium
binding?
a. EGFR
b. CaM Kinase
c. PKC
d. PI3K
3)Which of the following protein binds to PIP3?
a. EGFR
b. CaM Kinase
c. Akt
d. PI3K
4)Which of the following protein generates PIP3?
a. EGFR
b. CaM Kinase
c. Akt
d. PI3K
5)Which of the following protein cleaves PI (4, 5) P2?
a. EGFR
b. CaM Kinase
c. PLC
d. PI3K
Answer 1)
d. PI3K is a lipid kinase, where PI3 is the lipid, and K is for
Kinase
Answer 2)
b. CaM Kinase. Ca2+/calmodulin-dependent protein kinase
II (CaM kinase II or
CaMKII) is regulated by the Ca2+
/calmodulin complex.
Answer 3)
c. Protein kinase B (PKB), also known as Akt, is a
serine/threonine-specific protein kinase that binds to PIP3
Answer 4)
d. Phosphoinositide 3-kinases, also called phosphatidylinositol
3-kinases generate Phosphatidylinositol (3,4,5)-trisphosphate,
abbreviated PIP₃
Answer 5)
c. Phospholipase C (a class of membrane-associated enzymes) cleaves
PI (4, 5) P2
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