Question

Briefly describe Graft vs. Host Disease (GVHD)? What kinds of grafts does GVHD affect and what are some possible ways to prevent and treat it? How does the risk of GVHD relate to the value of a graft in your opinion?

Answer 1

Graft vs. host disease GVHd is characterized in many organs.GVHD is associated with stem cells transplants such as those that present bone marrow transplants.GVHD is a syndrome with the specific epithelial cells apoptosis.GVHD more common after the marrow has started to make healthy cells.This condition can be mild and severe and very serious.white blood cells of the donor's immune system which known as the graft or donated tissue that recognise the recipient as host and as foreign.WBC present within the transplanted tissue then attacks the recipient body cells that leads to GVHD.GVHD can occur after a blood transfusion.If the blood products used have not been treated with an approved pathogen reductive system.

Symptoms of GVHD based on how long someone had the conditions but may include rash abdominal pain and mouth ulcers.Mucosal damage to the female reproductive organs can result in pain and scarring.This appears in both acute and chronic GVHD.This can result in inability to have sexual intercourse.

Kind of graft or donated tissues is bone marrow or peripheral blood stem cells that view the recipient body as forein.And the donated cells or grafts or bone marrow attack the body.

Prevention:~

The T cells of umbilical cord blood have an inherent immunological immaturity.use of UCB stem cells in donor transplant has reduced the severity of GVHD.

Tacrolimus,Cyclosporin are common drugs used for GVHD prophylaxis.

Treatment:~

Prednisone is a important glucocorticoid that are used in treatment of both acute and chronic type GVHD.Prednisone suppressed the T-cell mediated immune onslaught on the host tissue.High doses of this glucocorticoid raises the risk of infection.

Cyclosporins and Tacrolimus are calcineurin inhibitors that both are different but the action are same.And both are used for treatment of GVHD.

MSCs(Mesenchymal Stromal cells) might be a treatment for GVHD.Alemtuzumab,Sirolimus,Pentostatin are inhibitors that used in treatment for GVHD.

In my opinion risk of GVHD relate to the value of a graft is very high serious disease because it's a chronic and acute both type of disease.In chronic GVHD most consistent risk is include prior acute GVHD,grafting with growth factors-mobilized blood cells.

Mortality were confirmed in chronic GVHD.

Severe chronic GVHD disease with lung liver involved is a subg with high mortality.