Question

Certain mutations in non-Hox genes actually produce homeotic mutants due to a failure to modulate chromatin acetylation appropriately. What is this influence on cellular "memory" called? which of these three? epigenetic RNA interference genetic

which of these three?

epigenetic

RNA interference

genetic

Answer 1

Sol:

• Epigenetic is the correct choice.
• Homeotic genes  regulate the development of anatomical structure of the body thus involving in body patterning.
• Homeotic mutants may occur due to failure of chromatin acetylation.
• Chromatin material consists of DNA and Histone proteins.
• Histone acetylation (where lysine residues in the histone protein core are acetylated by enzymes called histone acetyl transferases) reulates gene expression.
• This acetylation removes positive charge on histones thus decreasing the interaction of histones with negatively charged phosphate groups of DNA.
• As a result condensed chromatin is transformed into more relaxed structure that is directly associated with greater levels of gene transcription thus altering gene expression.