CFTR is a Cystic Fibrosis Transmembrane Receptor. It is an ABC-transporter and functions by using ATP to remove Cl- ions outside the cell.
Therefore, the CFTR is mutated, the Cl- ions can no longer be transported outside effectively. This results in the buildup of Cl- inside the cell. As a result, there is an osmotic imbalance that forces the water from outside the cell to inside to account for the increased chloride concentration. In this process, the extracellular space is depleted of water thereby making it thick and mucous rich.
The role of CFTR is to release Cl- ions outside. This results in the concentration of Cl- being built up outside the cell that triggers the water to flow outside. This function is compromised here.
Hence, the correct option is d.
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