What would you predict to be the free energies of reaction for the various reactions of the Krebs Cycle. Which would be strongly positive, which would be negative, and which would be zero?
The standard free energgy for the reactions in citric acid cycles are dependent on the enzymatic activity . The energy changes may be predicted as follows :
ENZYME | FREE ENERGY CHANGE |
Citrate synthase | -31.5 |
Aconitase | 5 |
Isocitrate dehydrogenase | -21 |
alpha-ketoglutarate dehydrogenase | -30 |
Succinyl- CoA synthetase | -2.1 |
Succinate dehydrogenase | +6 |
Fumarase | -3.4 |
Malate dehydrogenase | +29.7 |
The last reaction of the malate dehydrogenase will be strongly positive as it does not occur spontaneously and ends up by producing ATP. The strongly negative one will be the first reaction mediated by citrate synthase because that reaction marks the beginning of the citric acid cycle and requires to be spontaneous and quick to enhance the rate of reaction.
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