Replication slippage is a mutation that occur during the DNA
replication. It does the misparing of the complimentary strand of
DNA due to its denaturation and displacement.
This occurs due to the presence of tandem repeats found in the
site of replication.
Gene rearrangement can occur due to replication slippage. This
is its main importance. It cites to explain the instability of
microsatellite that relate to several human diseases.
The origin and evolution of repetitive DNA sequence is because
of this DNA slippage process.