Question

5) An inbred mouse of MHC haplotype b (MHCb) receives a bone marrow transplant from an F1 mouse (MHCaxb) that results from a cross between an MHCa and an MHCb mouse. What will happen?

a. The mouse will have no CD4+ T cells (no T helper cells)

b. The mouse will have severe autoimmune disorders

c. The mouse will have mature T cells with TCRs mostly restricted to recognizing the antigen they are specific for on MHCb proteins.

d. The mouse will have mature T cells with TCRs that can recognize the antigen they are specific for on MHCa or MHCb proteins.

Answer #6 please

6) This T cell restriction in (5) is because of

a. Negative selection of thymocytes by thymic cortical epithelial cells

b. Negative selection of thymocytes by thymic medullary epithelial cells

c. Positive selection of thymocytes by thymic cortical epithelial cells

d. Negative selection of thymocytes by macrophages and dendritic cells

Answer 1

5 ) option B

Mouse will have severe autoimmune disorder.

MHC molecules show codominant expression, if an individual has two alleles than both alleles are e pressed at same time on cell surface . If mouse with MHC haplotype B is transplanted withb MHC a/ b haplotype than the cell generated from the transplanted bone marriw have both MHC a/ b on their surface. And they will be considered as non self and destroyed and produce autoimmune response.

6) option c

Positive selection of thymocytes by thymic cortical epithelial cell.