Question

In many organisms, the nuclear envelope breaks down during mitosis. As part of this breakdown, the...

In many organisms, the nuclear envelope breaks down during mitosis. As part of this breakdown, the nuclear lamina that underlies the nuclear envelope breaks down. In fact, many investigators think that the breakdown of the lamina initiates envelope breakdown. Propose a reversible mechanism for controlling the polymerization state of the proteins that make up the nuclear lamina.

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Answer #1

Ans ) Well both of them , Reversible Phosphorylation and dephosphorylation provide a mechanism for regulating the polymerization of nuclear terms lamins. When, phosphorylated negative charge repulsion would lead to dissociation and after phosphorylation polymerization would occur .Specific protein kinase would be involved in the phosphorylation reaction and specific phosphatase in the phosphorylation reaction. These events could be regulated by various signaling pathways .

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