Question

If a disease has multiple genomic loci associated with it, is any particular loci likely to be a good drug target? What is the data on this so far?

Answer 1

A gene has many structual features associated with it. The most important regions are those which control the rate of transcription directly by promoting or preventing the movement of RNA polymerase over the cistron. Even if a gene is associated with multiple loci, it will tend to be down-regulated if the promoter region has been restricted.

Thus, any novel pharmaceutical product preventing free movement of RNA polymerase over cistron due to functional masking of the promoter, regulator or enhancer would prevent gene expression.