Question

What is the protein structure of CDK4?

Answer 1

CDK4 belongs to the cyclin-dependent kinase family and is also well known as a cell division protein kinase 4. It is also an enzyme and is encoded as CDK4 gene in human. The structure of CDK4 is typical to bilobal structure as that of other kinases. The protein structure has 5-stranded β-sheet and N-terminal domain (residues 1–96). In the cleft between the domains the ATP binding is located.

CDK4 is a protein coding gene there are various diseases associated with it like Melanoma and Myeloma. CDK4 controls the transition that takes place between G1 and the s phases of a cell cycle. Cell synthesizes DNA that are new is the S phase period and the cell divides during the process of mitosis.