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Which of the following statement is TRUE? Briefly explain why. A. Cells in the striatum that...

Which of the following statement is TRUE? Briefly explain why.

A. Cells in the striatum that project to GPi are excitatory

B. Stimulation of a cell in the striatum that projects to the GPi results an increase in the amount of inhibition reaching the thalamus

C. Stimulation of the GPi results in an increase in excitation of the Thalamus

D. A decrease in firing of GPi cells results in an increase in firing of Thalamic cells

E. None of the above are TRUE

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Answer #1

D.a decrease in the firing of GPi cells results in an increase in the firing of thalamic cells.

One of the principal connections in basal ganglia is connections between striatum, globus pallidus and thalamus.

Cells in striatum projects into GPi these are inhibitory .and the cells in GPi projects into thalamus which are also inhibitory (GABA).So the stimulation of cells in striatum results in inhibition of GPi.in turn firing of GPi is decreased and amount of inhibition reaching thalamus is decreased.since projections from GPi to thalamus is inhibitory, stimulating GPi results in decreased excitation of thalamus.

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