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Define the pharmacokinetic pathway in drug passage through the body?

Define the pharmacokinetic pathway in drug passage through the body?

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Answer #1

The multi-compartment model of pharmacokinetics states thats there are 5 steps that complete the passage of pharmaceutical drugs through the human body. These are -

  • Liberation (the release of drug inside the body)
  • Absorption (absorption of the drug by blood and entry into the circulatory system)
  • Distribution (the distribution of the drug to various parts of the body so that it can reach the target organ)
  • Metabolism (inactivation of the drug by the body as soon as it recognizes the drug as a foreign substance)
  • Excretion (removal of metabolized drug from the body)

The duration of each process and the metabolites produced further depend on other factors such as dosage of the drug, mode of administration of drug, clearance rate, the target organ, etc.

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