Question

How can the traumatic event in life cause depression? Explain the pathophysiology. ( In the short and understandable form please).

Answer 1

Soln- Depression is a major cause of morbidity worldwide. One of the risk factors that leads to depression is early traumatic events. Childhood trauma or events is associated with adulthood depression. PTSD is a common and chronic anxiety disorder that can result after exposure to a traumatic event. The adrenoreceptors are a group of G protein coupled receptors that stimulates CNS activity and sympathetic autonomic responses through cell bodies. These responses implicate it in selective attention to rewarding and aversive stimuli and stress and fear related responses. Through dysregulation of physiological mechanisms, hyperadrenergic activity has been linked to psychiatric conditions such as major depression, traumatic brain injury and anxiety disorders.