True or false. Pegylation is a strategy used by the therapeutic Pegasys to increase renal clearance. Please explain.
The statement is false.
Pegylation is a method used to reduce the renal clearance as by pegylation process the size and molecular weight of conjugated molecules increase which leads to the increased pharmacodynamics and pharmacokinetics. As this process on the other hand causes increase in the solubility of water . Thus pegylation also helps in increasing the half life of biomolecules as there ummunogenecity response is very low and are higly stable; which infact is easy to administer in low doses and with better efficiency.
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