Question

5-bromouracil causes mutations by

A. Causing double-strand DNA breaks

B. Converting adenine to hypoxanthine

C. producing thymidine dimers

D. inducing frameshift

E. undergoing tautomeric shifts during DNA replication which induces transition  

Answer 1

Answer =

5-bromouracil causes mutations by :

E. undergoing tautomeric shifts during DNA replication which induces transition  

Explanation = 5-bromouracil causes mutations by undergoing tautomeric shifts during DNA replication which induces transition.

5-bromouracil is a base analog of Thymine.

usually thymine base pairs with adenine, but it forms a mispairing with guanine, and causing a transition mutation during DNA replication.

the enol form of bromouracil base pairs with guanine .there is formation of rare O4-hydroxy tautomer of Bromouracil.