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In colon cancer progression, the first driver mutation is commonly a mutation to the KRas gene....

In colon cancer progression, the first driver mutation is commonly a mutation to the KRas gene.

True or False

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Answer #1

Answer: True.

Scientists identified six primary driver genes using the bioinformatics syudy, namely APC, KRAS, BRAF, P53, PIK3CA, and SMAD4. A meta-analysis showed that mutations of KRAS and p53 mutation were related to colon cancer metastasis.

KRAS (KRas) gene is known as proto-oncogene and when it is altered by mutation become an oncogene and contribute to cancers.

[Note: There does not appear to be a single genetic pathway to colon cancer (colorecal cancer), which in all cases is the same. The first mutation occurs in many cases in the APC gene.]

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