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How to 5-FU fluorouracil get in a cell? like by ion change or binding  to the receptor...

How to 5-FU fluorouracil get in a cell? like by ion change or binding  to the receptor

and what cause the thymidylate synthetase enzyme active?

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Answer #1

5-FU transported in to the cell by a saturable carrier (receptor) based transport system present in the cell membrane.

5-FU binds to thymidylate synthase (TS) enzyme and Interrupt synthesis thymidine, which is a nucleoside required for DNA replication. Thymidylate synthase methylates deoxyuridine monophosphate (dUMP) to form thymidine monophosphate (dTMP).

After binding with substrate dUMP TS enzyme takes on its active form and undergoes a change in conformation.

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