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What cell types do not require somatic gene rearrangement and clonal expansion to deal with a...

What cell types do not require somatic gene rearrangement and clonal expansion to deal with a pathogen (select all that apply)? a. Natural Killer cells b. T-cells c. B-cells d. Neutrophils e. Macrophages

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Answer #1

Clonal selection is present in the adaptive immunity. Where the immune elements are produced specifically for a perticular antigen. It can be only seen in case of humoral immunity. T-cell and B-cell undegoes clonal selection in the secondary lymphoid organ, spleen and lymph node.

On the other hand in case of innate immunity the fight against the antigen is in a generallised version, for broad spectrum. The cells like NK cells, nutrophils, macrophages do not need specilization through clonal selection. They can fight a wide range of antigen irrespective of the antigen's immunogenicity.

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