Question

[4/30/5] DESCRIBE THE GENETIC ALTERATIONS IN THE HUTCHINSON-GILFORD PROGERIA SYNDROME

[Typed please. (sometimes I can't understand the handwriting in some of the responses I get)]

Answer 1

Hutchinson progeria syndrome is characterized by rapid aging in the childhood and it is genetic disorder in which the children's when born looks normal but ages quickly and looks old within few years.

The disease is caused by mutation in lamin A gene LMNA which is essential component of scaffolding of nuclear envelope that surround the nucleus . Lamin A mutation results in abnormal shape of nuceae envelope and nuclear damage that leads to death of cells prematurely .