Question

(4/30) EXPLAIN WHAT IS THE ROLE OF VITAMIN D IN THE REGULATION OF PROTEINS IN RELATION TO THE CELL CYCLE AND SENESCENCE.

[Typed please. (sometimes I can't understand the handwriting in some of the responses I get) ]

Answer 1

vitamin D a secosteroid hormone, has beneficial effects on several body systems.

It occurs in two major forms,

1. vitaminD2 (ergocalciferol)

2. vitamin D3 (cholecalciferol)

Vitamin D causes cell cycle arrest at G0–G1 transition hence it will repress cell cycle progression.

It can alter regulatory proteins of the cell cycle like INK4, p53, and p21-activated kinase.

Vitamin D can modulate key mediators of apoptosis by inhibiting the anti-apoptotic proteins and/or by stimulating the pro-apoptotic proteins.

It is one of the key controllers of systemic inflammation, oxidative stress and mitochondrial respiratory function, and thus, the aging process in humans.