Question

Assume that a man with hemophilia marries a phenotypically normal woman whose father had hemophilia. What...

Assume that a man with hemophilia marries a phenotypically normal woman whose father had hemophilia. What is the probability that their first child will have hemophilia?

Select one:

a. 25%

b. 0%

c. 75%

d. 50%

e. 100%

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Answer #1

Answer :

Option d - 50%

Hemophilia is an X-linked recessive disorder. A male will be affected even if one gene of hemophilia is present because males have only one X chromosome. For females to be affected both the X chromosomes must have the hemophilic gene

In the question the male who is affected has the genotype XhY. The female he marries is a carrier since her father was hemophilic and has the genotype XhX.

The following cross shows the probability of children that will be affected, be carriers or be normal :

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