Question

n which situation below is a transplant contraindicated?

	1.	Heart transplant recipient with negative T cell cross match and positive B cell cross-match with donor cells
	2.	Kidney transplant recipient with positive T cell cross-match and negative B cell cross-match with donor cells
	3.	Liver transplant recipient with negative T cell cross-match and positive B cell cross-match with donor cells
	4.	All of the above

Answer 1

Ans: The correct option is D (All of the above).

A positive crossmatch means the patient has responded to the donor and thus, the transplant is not safe.

A negative crossmatch means the patient has not responded to the donor and thus, the transplant is safe.

Both T cell and B cell crossmatch should be negative for an effective transplant otherwise the graft will show either an early stage or late stage rejection.

T-cells crossmatch only express HLA class I while B cells express both HLA class I and II. So, crossmatch results should be negative for both T and B cells.