Question

n which situation below is a transplant contraindicated? 1. Heart transplant recipient with negative T cell...

n which situation below is a transplant contraindicated?

1.

Heart transplant recipient with negative T cell cross match and positive B cell cross-match with donor cells

2.

Kidney transplant recipient with positive T cell cross-match and negative B cell cross-match with donor cells

3.

Liver transplant recipient with negative T cell cross-match and positive B cell cross-match with donor cells

4.

All of the above

Homework Answers

Answer #1

Ans: The correct option is D (All of the above).

A positive crossmatch means the patient has responded to the donor and thus, the transplant is not safe.

A negative crossmatch means the patient has not responded to the donor and thus, the transplant is safe.

Both T cell and B cell crossmatch should be negative for an effective transplant otherwise the graft will show either an early stage or late stage rejection.

T-cells crossmatch only express HLA class I while B cells express both HLA class I and II. So, crossmatch results should be negative for both T and B cells.

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