Question

. S-phase arrest in response to glutamine deprivation in KRas-driven cancer cells can be reversed by...

. S-phase arrest in response to glutamine deprivation in KRas-driven cancer cells can be reversed by aspartate. A) True B) False

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Answer #1

The correct answer is True. Aspartate Rescues the cell from S-phase Arrest Caused by Suppression of Glutamine deprivation in KRas-driven Cancer Cells. The S- phase arrest occurs due to the deficiency of nucleotides for the DNA synthesis. Hence the cell is unable to synthesise DNA in S phase. Aspartate is the metabolite for purine and pyrimidine nucleotides. Thus aspartate helps in the synthesis of the nucleotides that in return help in the DNA synthesis and rescue the cell from S phase arrest.

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